Our Publications
Recent publications from Feucht & Leibold Labs
2024
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
Corina Amor, Inés Fernández-Maestre, ..., Judith Feucht, ..., Michel Sadelain & Scott W. Lowe
Nat. Aging. https://www.nature.com/articles/s43587-023-00560-5
Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
Josef Leibold*#, Kaloyan M. Tsanov*, Corina Amor*, ..., Judith Feucht, ..., Scott W. Lowe#
Nat. Cancer. https://www.nature.com/articles/s43018-023-00686-w
2023
LINKing signaling domains to enhance CAR T cells
Philip Bucher & Judith Feucht
Nat. Cancer. https://doi.org/10.1038/s43018-023-00538-7
TET2 guards against unchecked BATF3-induced CAR T cell expansion
Nayan Jain*, Zeguo Zhao*, Judith Feucht, ..., Michel Sadelain
Nature. https://doi.org/10.1038/s41586-022-05692-z
Novel extragenic genomic safe harbors for precise therapeutic T cell engineering
Ashlesha Odak, ..., Judith Feucht, ..., Michel Sadelain
Blood. https://doi.org/10.1182/blood.2022018924
2022
Preclinical Evaluation of CRISPR-Edited CAR-NK-92 Cells for Off-the-Shelf Treatment of AML and B-ALL
Guillermo Ureña-Bailén, ..., Judith Feucht, ..., Markus Mezger
Int J Mol Sci. https://doi.org/10.3390/ijms232112828
The oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma
Jens Bauer, ..., Philip Bucher, ..., Judith Feucht, ..., Juliane S. Walz
Nat Commun. https://doi.org/10.1038/s41467-022-33746-3
A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear Cell Renal Cell Carcinoma
Phillip M. Rappold, Lynda Vuong, Josef Leibold, ..., A. Ari Hakimi
Cancer Discov. https://doi.org/10.1158/2159-8290.CD-21-0925
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants
Francisco J. Sánchez-Rivera, Bianca J. Diaz, Edward R. Kastenhuber, Henri Schmidt, Alyna Katti, Margaret Kennedy, Vincent Tem, Yu-Jui Ho, Josef Leibold, ..., Lukas E. Dow
Nat Biotechnol. https://doi.org/10.1038/s41587-021-01172-3
Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer
Stella V. Paffenholz, ..., Josef Leibold# & Scott W. Lowe#
Proc Natl Acad Sci U S A. https://doi.org/10.1073/pnas.2117754119
HLA-independent T cell receptors for targeting tumors with low antigen density
Jorge Mansilla-Soto, Justin Eyquem, ..., Judith Feucht, ..., Michel Sadelain
Nat Med. https://doi.org/10.1038/s41591-021-01621-1
Protective T cell receptor identification for orthotopic reprogramming of immunity in refractory virus infections
Tanja A Stief, Theresa Kaeuferle, Thomas R Müller, ..., Judith Feucht, ...,Tobias Feuchtinger
Mol Ther. https://doi.org/10.1016/j.ymthe.2021.05.021
2020
Senolytic CAR T Cells in Solid Tumors and Age-Related Pathologies
Judith Feucht & Mohamed Abou-El-Enein
Mol Ther. https://doi.org/10.1016/j.ymthe.2020.08.011
Function and evolution of the prototypic CD28ζ and 4-1BBζ chimeric antigen receptors
Judith Feucht & Michel Sadelain
Immunooncol Technol. https://doi.org/10.1016/j.iotech.2020.09.001
Senolytic CAR T cells reverse senescence-associated pathologies
Corina Amor*, Judith Feucht*, Josef Leibold*, ..., Michel Sadelain & Scott W. Lowe
Nature. https://doi.org/10.1038/s41586-020-2403-9
Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis
Josef Leibold*, Marcus Ruscetti*, Zhen Cao*, ..., Judith Feucht, ..., Charles L. Sawyers & Scott W. Lowe
Cancer Discov. https://doi.org/10.1158/2159-8290.CD-19-1242
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer
Marcus Ruscetti, John P. Morris IV, Riccardo Mezzadra, James Russell, Josef Leibold, ..., Scott W. Lowe
Cell. https://doi.org/10.1016/j.cell.2020.03.008
2019
Efficacy, safety and feasibility of fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting in pediatric patients receiving moderately and highly emetogenic chemotherapy - results of a non-interventional observation study
Semjon Willier, ..., Judith Feucht, ..., Michaela Döring
BMC Cancer. https://doi.org/10.1186/s12885-019-6252-6
Comparison of procalcitonin and C-reactive protein as early diagnostic marker for the identification of transplant-related adverse events after allogeneic hematopoietic stem cell transplantation in pediatric patients
Karin Melanie Cabanillas Stanchi, ..., Judith Feucht, ..., Michaela Döring
J Cancer Res Clin Oncol. https://doi.org/10.1007/s00432-019-03008-9
Efficacy, Safety And Feasibility Of Antiemetic Prophylaxis With Fosaprepitant, Granisetron And Dexamethasone In Pediatric Patients With Hemato-Oncological Malignancies
Karin Melanie Cabanillas Stanchi, Martin Ebinger, ..., Judith Feucht, ..., Michaela Döring
Drug Des Devel Ther. https://doi.org/10.2147/DDDT.S214264
Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy
Franziska Blaeschke, ..., Judith Feucht, ..., Tobias Feuchtinger
Cytotherapy. https://doi.org/10.1016/j.jcyt.2019.06.009
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
Viraj R. Sanghvi, Josef Leibold, ..., Hans-Guido Wendel
Cell. https://doi.org/10.1016/j.cell.2019.07.031
Induction of Oxidative Stress Through Inhibition of Thioredoxin Reductase 1 Is an Effective Therapeutic Approach for Hepatocellular Carcinoma
Derek Lee, Iris Ming-Jing Xu, David Kung-Chun Chiu, Josef Leibold, ..., Irene Oi-Lin Ng & Carmen Chak-Lui Wong
Hepatology. https://doi.org/10.1002/hep.30467
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency
Judith Feucht*, Jie Sun*, ..., Josef Leibold, ..., Michel Sadelain
Nat Med. https://doi.org/10.1038/s41591-018-0290-5
2018
NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
Marcus Ruscetti*, Josef Leibold*, Matthew J. Bott*, ..., Judith Feucht, ..., Scott W. Lowe
Science. https://doi.org/10.1126/science.aas9090
Induction of a central memory and stem cell memory phenotype in functionally active CD4+ and CD8+ CAR T cells produced in an automated good manufacturing practice system for the treatment of CD19+ acute lymphoblastic leukemia
Franziska Blaeschke, ..., Judith Feucht & Tobias Feuchtinger
Cancer Immunol. Immunother. https://doi.org/10.1007/s00262-018-2155-7
Quantitative self-assembly prediction yields targeted nanomedicines
Yosi Shamay, ..., Josef Leibold, ..., Daniel A. Heller
Nat Mater. https://doi.org/10.1038/s41563-017-0007-z
2015
Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT
Judith Feucht, ..., Tobias Feuchtinger
Blood. https://doi.org/10.1182/blood-2014-06-573725
For complete publication list see PubMed